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MCM ring hexamerization is a prerequisite for DNA-binding

The hexameric Minichromosome Maintenance (MCM) protein complex forms a ring that unwinds DNA at the replication fork in eukaryotes and archaea. Our recent crystal structure of an archaeal MCM N-terminal domain bound to single-stranded DNA (ssDNA) revealed ssDNA associating across tight subunit inter...

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Detalles Bibliográficos
Autores principales:	Froelich, Clifford A., Nourse, Amanda, Enemark, Eric J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627082/ https://www.ncbi.nlm.nih.gov/pubmed/26365238 http://dx.doi.org/10.1093/nar/gkv914

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