A structural approach reveals how neighbouring C2H2 zinc fingers influence DNA binding specificity

Development of an accurate protein–DNA recognition code that can predict DNA specificity from protein sequence is a central problem in biology. C(2)H(2) zinc fingers constitute by far the largest family of DNA binding domains and their binding specificity has been studied intensively. However, despi...

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Detalles Bibliográficos
Autores principales: Garton, Michael, Najafabadi, Hamed S., Schmitges, Frank W., Radovani, Ernest, Hughes, Timothy R., Kim, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627083/
https://www.ncbi.nlm.nih.gov/pubmed/26384429
http://dx.doi.org/10.1093/nar/gkv919

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