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Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly
Small RNA silencing is mediated by the effector RNA-induced silencing complex (RISC) that consists of an Argonaute protein (AGOs 1–4 in humans). A fundamental step during RISC assembly involves the separation of two strands of a small RNA duplex, whereby only the guide strand is retained to form the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627090/ https://www.ncbi.nlm.nih.gov/pubmed/26384428 http://dx.doi.org/10.1093/nar/gkv937 |