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Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides

We have recently shown that the incorporation of modified nucleotides such as 5-N-carboxamide-deoxyuridines into random nucleic acid libraries improves success rates in SELEX experiments and facilitates the identification of ligands with slow off-rates. Here we report the impact of these modificatio...

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Detalles Bibliográficos
Autores principales:	Wolk, Steven K., Shoemaker, Richard K., Mayfield, Wes S., Mestdagh, Andrew L., Janjic, Nebojsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627095/ https://www.ncbi.nlm.nih.gov/pubmed/26438535 http://dx.doi.org/10.1093/nar/gkv981

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