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Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa

In resource-limited settings, early mortality on antiretroviral therapy (ART) is approximately 10%; yet, it is unclear how much of that mortality occurs in care or after lost to follow-up. We assessed mortality rates and predictors of death among 12,222 nonpregnant ART-naive adults initiating first-...

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Autores principales: Budgell, Eric P., Maskew, Mhairi, Long, Lawrence, Sanne, Ian, Fox, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627171/
https://www.ncbi.nlm.nih.gov/pubmed/26181816
http://dx.doi.org/10.1097/QAI.0000000000000755
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author Budgell, Eric P.
Maskew, Mhairi
Long, Lawrence
Sanne, Ian
Fox, Matthew P.
author_facet Budgell, Eric P.
Maskew, Mhairi
Long, Lawrence
Sanne, Ian
Fox, Matthew P.
author_sort Budgell, Eric P.
collection PubMed
description In resource-limited settings, early mortality on antiretroviral therapy (ART) is approximately 10%; yet, it is unclear how much of that mortality occurs in care or after lost to follow-up. We assessed mortality rates and predictors of death among 12,222 nonpregnant ART-naive adults initiating first-line ART between April 2004 and May 2012 in South Africa, stratified by person-years in care and lost. We found 14.6% of patients died and being lost accounted for a minority of deaths across multiple definitions of loss (population attributable-risk percent ranged from 10.4% to 42.5%). Although mortality rates in patients lost were much higher than in care, most ART-related mortality occurred on treatment.
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spelling pubmed-46271712015-11-20 Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa Budgell, Eric P. Maskew, Mhairi Long, Lawrence Sanne, Ian Fox, Matthew P. J Acquir Immune Defic Syndr Epidemiology and Prevention In resource-limited settings, early mortality on antiretroviral therapy (ART) is approximately 10%; yet, it is unclear how much of that mortality occurs in care or after lost to follow-up. We assessed mortality rates and predictors of death among 12,222 nonpregnant ART-naive adults initiating first-line ART between April 2004 and May 2012 in South Africa, stratified by person-years in care and lost. We found 14.6% of patients died and being lost accounted for a minority of deaths across multiple definitions of loss (population attributable-risk percent ranged from 10.4% to 42.5%). Although mortality rates in patients lost were much higher than in care, most ART-related mortality occurred on treatment. JAIDS Journal of Acquired Immune Deficiency Syndromes 2015-11-01 2015-10-15 /pmc/articles/PMC4627171/ /pubmed/26181816 http://dx.doi.org/10.1097/QAI.0000000000000755 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Epidemiology and Prevention
Budgell, Eric P.
Maskew, Mhairi
Long, Lawrence
Sanne, Ian
Fox, Matthew P.
Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title_full Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title_fullStr Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title_full_unstemmed Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title_short Brief Report: Does Most Mortality in Patients on ART Occur in Care or After Lost to Follow-Up? Evidence From the Themba Lethu Clinic, South Africa
title_sort brief report: does most mortality in patients on art occur in care or after lost to follow-up? evidence from the themba lethu clinic, south africa
topic Epidemiology and Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627171/
https://www.ncbi.nlm.nih.gov/pubmed/26181816
http://dx.doi.org/10.1097/QAI.0000000000000755
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