Cargando…

Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial

BACKGROUND: This study was designed to evaluate the effect of cumin on nonalcoholic steatohepatitis (NASH) in compare to placebo. MATERIALS AND METHODS: One hundred patients with histopathological diagnosis NASH in two groups of case and control received oral cumin capsule or placebo thrice daily fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Shavakhi, Ahmad, Torki, Masoumeh, Khodadoostan, Mahsa, Shavakhi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627178/
https://www.ncbi.nlm.nih.gov/pubmed/26605241
http://dx.doi.org/10.4103/2277-9175.166149
_version_ 1782398240432324608
author Shavakhi, Ahmad
Torki, Masoumeh
Khodadoostan, Mahsa
Shavakhi, Sara
author_facet Shavakhi, Ahmad
Torki, Masoumeh
Khodadoostan, Mahsa
Shavakhi, Sara
author_sort Shavakhi, Ahmad
collection PubMed
description BACKGROUND: This study was designed to evaluate the effect of cumin on nonalcoholic steatohepatitis (NASH) in compare to placebo. MATERIALS AND METHODS: One hundred patients with histopathological diagnosis NASH in two groups of case and control received oral cumin capsule or placebo thrice daily for 6 months. Clinical and laboratory data were body mass index (BMI), serum triglyceride, serum total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting blood sugar (FBS), steatosis grade, and side-effects and were measured at baseline and after treatment period using standard clinical chemistry techniques. The grade of steatosis was assessed by liver sonography in 3 stages (mild, moderate and severe). RESULTS: Of 100 eligible patients during follow-up 10/50 cases and 9/50 controls were excluded. At baseline and after treatment BMI, triglyceride, cholesterol, ALT, AST, HDL, LDL, and FBS were not statistically significant between groups (P ≥ 0.5). BMI, triglyceride, cholesterol, ALT, AST, LDL, and FBS after treatment decreased compare to baseline but were not statistically significant (P ≥ 0.5). The mean of changes in the level of BMI, triglyceride, cholesterol, ALT, LDL and FBS were not statistically significant (P ≥ 0.5). The mean of changes in AST and HDL between groups was significant (P < 0.05). The grade of steatosis before and after treatment between studied groups was not statistically significant (P ≥ 0.5). Side-effects were not statistically significant among the two groups. CONCLUSION: Findings show that there the effect of cumin in in the treatment of NASH was not significantly different in compare to placebo.
format Online
Article
Text
id pubmed-4627178
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-46271782015-11-24 Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial Shavakhi, Ahmad Torki, Masoumeh Khodadoostan, Mahsa Shavakhi, Sara Adv Biomed Res Original Article BACKGROUND: This study was designed to evaluate the effect of cumin on nonalcoholic steatohepatitis (NASH) in compare to placebo. MATERIALS AND METHODS: One hundred patients with histopathological diagnosis NASH in two groups of case and control received oral cumin capsule or placebo thrice daily for 6 months. Clinical and laboratory data were body mass index (BMI), serum triglyceride, serum total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting blood sugar (FBS), steatosis grade, and side-effects and were measured at baseline and after treatment period using standard clinical chemistry techniques. The grade of steatosis was assessed by liver sonography in 3 stages (mild, moderate and severe). RESULTS: Of 100 eligible patients during follow-up 10/50 cases and 9/50 controls were excluded. At baseline and after treatment BMI, triglyceride, cholesterol, ALT, AST, HDL, LDL, and FBS were not statistically significant between groups (P ≥ 0.5). BMI, triglyceride, cholesterol, ALT, AST, LDL, and FBS after treatment decreased compare to baseline but were not statistically significant (P ≥ 0.5). The mean of changes in the level of BMI, triglyceride, cholesterol, ALT, LDL and FBS were not statistically significant (P ≥ 0.5). The mean of changes in AST and HDL between groups was significant (P < 0.05). The grade of steatosis before and after treatment between studied groups was not statistically significant (P ≥ 0.5). Side-effects were not statistically significant among the two groups. CONCLUSION: Findings show that there the effect of cumin in in the treatment of NASH was not significantly different in compare to placebo. Medknow Publications & Media Pvt Ltd 2015-09-28 /pmc/articles/PMC4627178/ /pubmed/26605241 http://dx.doi.org/10.4103/2277-9175.166149 Text en Copyright: © 2015 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shavakhi, Ahmad
Torki, Masoumeh
Khodadoostan, Mahsa
Shavakhi, Sara
Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title_full Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title_fullStr Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title_full_unstemmed Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title_short Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial
title_sort effects of cumin on nonalcoholic steatohepatitis: a double blind, randomised, controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627178/
https://www.ncbi.nlm.nih.gov/pubmed/26605241
http://dx.doi.org/10.4103/2277-9175.166149
work_keys_str_mv AT shavakhiahmad effectsofcuminonnonalcoholicsteatohepatitisadoubleblindrandomisedcontrolledtrial
AT torkimasoumeh effectsofcuminonnonalcoholicsteatohepatitisadoubleblindrandomisedcontrolledtrial
AT khodadoostanmahsa effectsofcuminonnonalcoholicsteatohepatitisadoubleblindrandomisedcontrolledtrial
AT shavakhisara effectsofcuminonnonalcoholicsteatohepatitisadoubleblindrandomisedcontrolledtrial