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Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

Human tumors exhibit increased glucose uptake and metabolism as a result of high demand for ATP and anabolic substrates and this metabolotype is a negative prognostic indicator for survival. Recent studies have demonstrated that cancer cells from several tissue origins and genetic backgrounds requir...

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Detalles Bibliográficos
Autores principales:	Chesney, Jason, Clark, Jennifer, Lanceta, Lilibeth, Trent, John O., Telang, Sucheta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627231/ https://www.ncbi.nlm.nih.gov/pubmed/26221874

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