Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme – phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis

Phosphoglycerate mutase (PGAM), a conserved, glycolytic enzyme has been found in nucleoli of cancer cells. Here, we present evidence that accumulation of PGAM in the nucleolus is a universal phenomenon concerning not only neoplastically transformed but also non-malignant cells. Nucleolar localizatio...

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Detalles Bibliográficos
Autores principales: Gizak, Agnieszka, Grenda, Marcin, Mamczur, Piotr, Wisniewski, Janusz, Sucharski, Filip, Silberring, Jerzy, McCubrey, James A., Wisniewski, Jacek R., Rakus, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627304/
https://www.ncbi.nlm.nih.gov/pubmed/26033454

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