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The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5
Carfilzomib (CFZ) is a second generation proteasome inhibitor approved for the treatment of patients with multiple myeloma. It induces apoptosis in human cancer cells; but the underlying mechanisms remain undefined. In the present study, we show that CFZ decreases the survival of several human cance...
Autores principales: | Han, Bo, Yao, Weilong, Oh, You-Take, Tong, Jing-Shan, Li, Shaohua, Deng, Jiusheng, Yue, Ping, Khuri, Fadlo R., Sun, Shi-Yong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627326/ https://www.ncbi.nlm.nih.gov/pubmed/26009898 |
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