The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease

OBJECTIVE: Relatively little is known about the effects of deep brain stimulation on non-motor symptoms. The aim of this pilot study was to assess the impact of deep brain stimulation on sleep and olfactory function in Parkinson’s disease. METHODS: Subjective sleep quality and olfactory testing were...

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Autores principales: Breen, David P, Low, Hu Liang, Misbahuddin, Anjum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627383/
https://www.ncbi.nlm.nih.gov/pubmed/26535069
http://dx.doi.org/10.2174/1874205X01509010070
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author Breen, David P
Low, Hu Liang
Misbahuddin, Anjum
author_facet Breen, David P
Low, Hu Liang
Misbahuddin, Anjum
author_sort Breen, David P
collection PubMed
description OBJECTIVE: Relatively little is known about the effects of deep brain stimulation on non-motor symptoms. The aim of this pilot study was to assess the impact of deep brain stimulation on sleep and olfactory function in Parkinson’s disease. METHODS: Subjective sleep quality and olfactory testing were performed on 11 consecutive Parkinson’s disease patients (eight men and three women) undergoing bilateral subthalamic nucleus stimulation. All patients consented to undergo clinical assessments prior to the procedure, and at regular intervals afterwards. RESULTS: Subjective sleep quality improved at six months following deep brain stimulation and this benefit was sustained in the majority of patients at later follow-up assessments. There was no significant change in olfactory function following deep brain stimulation. CONCLUSIONS: In addition to having beneficial effects on motor function and quality of life, bilateral subthalamic nucleus stimulation improves subjective sleep quality in Parkinson’s disease.
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spelling pubmed-46273832015-11-03 The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease Breen, David P Low, Hu Liang Misbahuddin, Anjum Open Neurol J Article OBJECTIVE: Relatively little is known about the effects of deep brain stimulation on non-motor symptoms. The aim of this pilot study was to assess the impact of deep brain stimulation on sleep and olfactory function in Parkinson’s disease. METHODS: Subjective sleep quality and olfactory testing were performed on 11 consecutive Parkinson’s disease patients (eight men and three women) undergoing bilateral subthalamic nucleus stimulation. All patients consented to undergo clinical assessments prior to the procedure, and at regular intervals afterwards. RESULTS: Subjective sleep quality improved at six months following deep brain stimulation and this benefit was sustained in the majority of patients at later follow-up assessments. There was no significant change in olfactory function following deep brain stimulation. CONCLUSIONS: In addition to having beneficial effects on motor function and quality of life, bilateral subthalamic nucleus stimulation improves subjective sleep quality in Parkinson’s disease. Bentham Open 2015-09-30 /pmc/articles/PMC4627383/ /pubmed/26535069 http://dx.doi.org/10.2174/1874205X01509010070 Text en © Breen et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Breen, David P
Low, Hu Liang
Misbahuddin, Anjum
The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title_full The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title_fullStr The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title_full_unstemmed The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title_short The Impact of Deep Brain Stimulation on Sleep and Olfactory Function in Parkinson’s Disease
title_sort impact of deep brain stimulation on sleep and olfactory function in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627383/
https://www.ncbi.nlm.nih.gov/pubmed/26535069
http://dx.doi.org/10.2174/1874205X01509010070
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