Network analysis of gene essentiality in functional genomics experiments

Many genomic techniques have been developed to study gene essentiality genome-wide, such as CRISPR and shRNA screens. Our analyses of public CRISPR screens suggest protein interaction networks, when integrated with gene expression or histone marks, are highly predictive of gene essentiality. Meanwhi...

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Detalles Bibliográficos
Autores principales: Jiang, Peng, Wang, Hongfang, Li, Wei, Zang, Chongzhi, Li, Bo, Wong, Yinling J., Meyer, Cliff, Liu, Jun S., Aster, Jon C., Liu, X. Shirley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627418/
https://www.ncbi.nlm.nih.gov/pubmed/26518695
http://dx.doi.org/10.1186/s13059-015-0808-9

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