Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction

Every person carries a vast repertoire of CD4(+) T-helper cells and CD8(+) cytotoxic T cells for a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell receptor (TCR) is a key step during T-cell development, but how a single T cell commits to become either CD4(+) o...

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Detalles Bibliográficos
Autores principales: Klarenbeek, Paul L., Doorenspleet, Marieke E., Esveldt, Rebecca E. E., van Schaik, Barbera D. C., Lardy, Neubury, van Kampen, Antoine H. C., Tak, Paul P., Plenge, Robert M., Baas, Frank, de Bakker, Paul I. W., de Vries, Niek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627806/
https://www.ncbi.nlm.nih.gov/pubmed/26517366
http://dx.doi.org/10.1371/journal.pone.0140815

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