Cargando…

Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria

Bacterial infections caused by multidrug resistant phenotypes constitute a worldwide health concern. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five medicinal plants: Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, D...

Descripción completa

Detalles Bibliográficos
Autores principales: Seukep, Jackson A., Ngadjui, Bonaventure, Kuete, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627964/
https://www.ncbi.nlm.nih.gov/pubmed/26543702
http://dx.doi.org/10.1186/s40064-015-1375-y
_version_ 1782398353583112192
author Seukep, Jackson A.
Ngadjui, Bonaventure
Kuete, Victor
author_facet Seukep, Jackson A.
Ngadjui, Bonaventure
Kuete, Victor
author_sort Seukep, Jackson A.
collection PubMed
description Bacterial infections caused by multidrug resistant phenotypes constitute a worldwide health concern. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five medicinal plants: Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against a panel of 28 multidrug resistant Gram-negative bacterial strains. The liquid broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The best activity was recorded with Canarium schweinfurthii bark extract, MIC values ranging from 32 to 1024 µg/mL being recorded against 85.7 % tested bacteria. Broad spectra of antibacterial activities were also obtained with both bark and leaf extracts from Myrianthus arboreus (78.6 %) as well as the bark extract from Fagara macrophylla (75.0 %). The lowest MIC value of 32 µg/mL was obtained with Canarium schweinfurthii bark extract against Klebsiella pneumoniae KP63 strain. The results of this work provide baseline information for the use of the studied plants, and mostly Fagara macrophylla, Canarium schweinfurthii and Myrianthus arboreus in the treatment of bacterial infections including multidrug resistant phenotypes.
format Online
Article
Text
id pubmed-4627964
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-46279642015-11-05 Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria Seukep, Jackson A. Ngadjui, Bonaventure Kuete, Victor Springerplus Research Bacterial infections caused by multidrug resistant phenotypes constitute a worldwide health concern. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of five medicinal plants: Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against a panel of 28 multidrug resistant Gram-negative bacterial strains. The liquid broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The best activity was recorded with Canarium schweinfurthii bark extract, MIC values ranging from 32 to 1024 µg/mL being recorded against 85.7 % tested bacteria. Broad spectra of antibacterial activities were also obtained with both bark and leaf extracts from Myrianthus arboreus (78.6 %) as well as the bark extract from Fagara macrophylla (75.0 %). The lowest MIC value of 32 µg/mL was obtained with Canarium schweinfurthii bark extract against Klebsiella pneumoniae KP63 strain. The results of this work provide baseline information for the use of the studied plants, and mostly Fagara macrophylla, Canarium schweinfurthii and Myrianthus arboreus in the treatment of bacterial infections including multidrug resistant phenotypes. Springer International Publishing 2015-10-01 /pmc/articles/PMC4627964/ /pubmed/26543702 http://dx.doi.org/10.1186/s40064-015-1375-y Text en © Seukep et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Seukep, Jackson A.
Ngadjui, Bonaventure
Kuete, Victor
Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title_full Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title_fullStr Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title_full_unstemmed Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title_short Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
title_sort antibacterial activities of fagara macrophylla, canarium schweinfurthii, myrianthus arboreus, dischistocalyx grandifolius and tragia benthamii against multi-drug resistant gram-negative bacteria
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627964/
https://www.ncbi.nlm.nih.gov/pubmed/26543702
http://dx.doi.org/10.1186/s40064-015-1375-y
work_keys_str_mv AT seukepjacksona antibacterialactivitiesoffagaramacrophyllacanariumschweinfurthiimyrianthusarboreusdischistocalyxgrandifoliusandtragiabenthamiiagainstmultidrugresistantgramnegativebacteria
AT ngadjuibonaventure antibacterialactivitiesoffagaramacrophyllacanariumschweinfurthiimyrianthusarboreusdischistocalyxgrandifoliusandtragiabenthamiiagainstmultidrugresistantgramnegativebacteria
AT kuetevictor antibacterialactivitiesoffagaramacrophyllacanariumschweinfurthiimyrianthusarboreusdischistocalyxgrandifoliusandtragiabenthamiiagainstmultidrugresistantgramnegativebacteria