Stem cell transplantation therapy in Parkinson’s disease

Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repai...

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Autores principales: Fu, Mu-Hui, Li, Chia-Ling, Lin, Hsiu-Lien, Chen, Pei-Chun, Calkins, Marcus J., Chang, Yu-Fan, Cheng, Pei-Hsun, Yang, Shang-Hsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628010/
https://www.ncbi.nlm.nih.gov/pubmed/26543732
http://dx.doi.org/10.1186/s40064-015-1400-1
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author Fu, Mu-Hui
Li, Chia-Ling
Lin, Hsiu-Lien
Chen, Pei-Chun
Calkins, Marcus J.
Chang, Yu-Fan
Cheng, Pei-Hsun
Yang, Shang-Hsun
author_facet Fu, Mu-Hui
Li, Chia-Ling
Lin, Hsiu-Lien
Chen, Pei-Chun
Calkins, Marcus J.
Chang, Yu-Fan
Cheng, Pei-Hsun
Yang, Shang-Hsun
author_sort Fu, Mu-Hui
collection PubMed
description Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease.
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spelling pubmed-46280102015-11-05 Stem cell transplantation therapy in Parkinson’s disease Fu, Mu-Hui Li, Chia-Ling Lin, Hsiu-Lien Chen, Pei-Chun Calkins, Marcus J. Chang, Yu-Fan Cheng, Pei-Hsun Yang, Shang-Hsun Springerplus Review Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease. Springer International Publishing 2015-10-13 /pmc/articles/PMC4628010/ /pubmed/26543732 http://dx.doi.org/10.1186/s40064-015-1400-1 Text en © Fu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Fu, Mu-Hui
Li, Chia-Ling
Lin, Hsiu-Lien
Chen, Pei-Chun
Calkins, Marcus J.
Chang, Yu-Fan
Cheng, Pei-Hsun
Yang, Shang-Hsun
Stem cell transplantation therapy in Parkinson’s disease
title Stem cell transplantation therapy in Parkinson’s disease
title_full Stem cell transplantation therapy in Parkinson’s disease
title_fullStr Stem cell transplantation therapy in Parkinson’s disease
title_full_unstemmed Stem cell transplantation therapy in Parkinson’s disease
title_short Stem cell transplantation therapy in Parkinson’s disease
title_sort stem cell transplantation therapy in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628010/
https://www.ncbi.nlm.nih.gov/pubmed/26543732
http://dx.doi.org/10.1186/s40064-015-1400-1
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