Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation

BACKGROUND: Currently there is no reliable medical treatment for aortic regurgitation (AR). METHODS: Thirty-nine Sprague–Dawley rats underwent creation of AR or sham operation. Treated rats were assigned to early or late institution of sildenafil therapy (100 mg/kg/day) for a total of 10 weeks. Trea...

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Detalles Bibliográficos
Autores principales: Eskesen, Kristian, Olsen, Niels Thue, Dimaano, Veronica L., Fritz-Hansen, Thomas, Sogaard, Peter, Chakir, Khalid, Steenbergen, Charles, Kass, David, Abraham, Theodore P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628012/
https://www.ncbi.nlm.nih.gov/pubmed/26543727
http://dx.doi.org/10.1186/s40064-015-1317-8

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