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CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients

CYP3A5 and ABCB1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements, but the conclusion in the current reports were inconformity. Sirolimus are also metabolized by CYP3A subfamily and are substrates of the P-gp. The aim was to determine whether these pol...

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Detalles Bibliográficos
Autores principales:	Li, Yi, Yan, Lin, Shi, Yunying, Bai, Yangjuan, Tang, Jiangtao, Wang, Lanlan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628029/ https://www.ncbi.nlm.nih.gov/pubmed/26543771 http://dx.doi.org/10.1186/s40064-015-1425-5

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