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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383

PURPOSE: To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383. METHODS: For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate active uptake and passive...

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Detalles Bibliográficos
Autores principales:	Ufuk, Ayşe, Somers, Graham, Houston, J. Brian, Galetin, Aleksandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628094/ https://www.ncbi.nlm.nih.gov/pubmed/26224396 http://dx.doi.org/10.1007/s11095-015-1753-8

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