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Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor
The aim of this retrospective study was to investigate characteristics of organizing pneumonia (OP) after stereotactic body radiotherapy (SBRT) for lung tumor. Between September 2010 and June 2014, patients who were diagnosed as Stage I lung cancer and treated with SBRT at our institution were inclu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628220/ https://www.ncbi.nlm.nih.gov/pubmed/26338993 http://dx.doi.org/10.1093/jrr/rrv049 |
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author | Ochiai, Satoru Nomoto, Yoshihito Yamashita, Yasufumi Murashima, Shuuichi Hasegawa, Daisuke Kurobe, Yusuke Toyomasu, Yutaka Kawamura, Tomoko Takada, Akinori II, Noriko |
author_facet | Ochiai, Satoru Nomoto, Yoshihito Yamashita, Yasufumi Murashima, Shuuichi Hasegawa, Daisuke Kurobe, Yusuke Toyomasu, Yutaka Kawamura, Tomoko Takada, Akinori II, Noriko |
author_sort | Ochiai, Satoru |
collection | PubMed |
description | The aim of this retrospective study was to investigate characteristics of organizing pneumonia (OP) after stereotactic body radiotherapy (SBRT) for lung tumor. Between September 2010 and June 2014, patients who were diagnosed as Stage I lung cancer and treated with SBRT at our institution were included in this study. A total of 78 patients (47 males with a median age of 80 years) were analyzed. The median follow-up period was 23 months. Five patients (6.4%) developed OP at 6–18 months after SBRT. The cumulative incidence of OP was 4.3% (95% confidence interval [CI], 1.1–11.0) and 8.2% (95% CI, 2.9–17.0) at 1 and 2 years, respectively. Tumor location (superior and middle lobe vs inferior lobe) was shown to be a borderline significant factor for the occurrence of OP (P = 0.069). In the subgroup analysis of patients with a radiographic follow-up period at least 6 months, or who died within 6 months after SBRT, 7 of 72 patients (9.7%) developed Grade 2 or 3 radiation pneumonitis (G2/3 RP) at 2–4 months after SBRT. A statistically significant association between G2/3 RP in the subacute phase and OP was shown (P = 0.040). In two of the five patients who developed OP, the symptoms and radiographic change were improved rapidly by corticosteroid administration. One patient had relapsed OP after suspending the treatment and re-administration was required. Three patients with minor symptoms were managed without corticosteroid administration and OP resolved without any relapse. The radiation-induced OP should be considered as one of the late lung injuries after SBRT for lung tumors. |
format | Online Article Text |
id | pubmed-4628220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46282202015-11-02 Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor Ochiai, Satoru Nomoto, Yoshihito Yamashita, Yasufumi Murashima, Shuuichi Hasegawa, Daisuke Kurobe, Yusuke Toyomasu, Yutaka Kawamura, Tomoko Takada, Akinori II, Noriko J Radiat Res Oncology The aim of this retrospective study was to investigate characteristics of organizing pneumonia (OP) after stereotactic body radiotherapy (SBRT) for lung tumor. Between September 2010 and June 2014, patients who were diagnosed as Stage I lung cancer and treated with SBRT at our institution were included in this study. A total of 78 patients (47 males with a median age of 80 years) were analyzed. The median follow-up period was 23 months. Five patients (6.4%) developed OP at 6–18 months after SBRT. The cumulative incidence of OP was 4.3% (95% confidence interval [CI], 1.1–11.0) and 8.2% (95% CI, 2.9–17.0) at 1 and 2 years, respectively. Tumor location (superior and middle lobe vs inferior lobe) was shown to be a borderline significant factor for the occurrence of OP (P = 0.069). In the subgroup analysis of patients with a radiographic follow-up period at least 6 months, or who died within 6 months after SBRT, 7 of 72 patients (9.7%) developed Grade 2 or 3 radiation pneumonitis (G2/3 RP) at 2–4 months after SBRT. A statistically significant association between G2/3 RP in the subacute phase and OP was shown (P = 0.040). In two of the five patients who developed OP, the symptoms and radiographic change were improved rapidly by corticosteroid administration. One patient had relapsed OP after suspending the treatment and re-administration was required. Three patients with minor symptoms were managed without corticosteroid administration and OP resolved without any relapse. The radiation-induced OP should be considered as one of the late lung injuries after SBRT for lung tumors. Oxford University Press 2015-11 2015-09-02 /pmc/articles/PMC4628220/ /pubmed/26338993 http://dx.doi.org/10.1093/jrr/rrv049 Text en © The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Oncology Ochiai, Satoru Nomoto, Yoshihito Yamashita, Yasufumi Murashima, Shuuichi Hasegawa, Daisuke Kurobe, Yusuke Toyomasu, Yutaka Kawamura, Tomoko Takada, Akinori II, Noriko Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title | Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title_full | Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title_fullStr | Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title_full_unstemmed | Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title_short | Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
title_sort | radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628220/ https://www.ncbi.nlm.nih.gov/pubmed/26338993 http://dx.doi.org/10.1093/jrr/rrv049 |
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