SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

BACKGROUND: Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission of infectious prions. Cell-to-cell transmission of SOD1 protein aggregates is dependent on fluid-phase endocytosis pathways, alt...

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Detalles Bibliográficos
Autores principales: Zeineddine, Rafaa, Pundavela, Jay F., Corcoran, Lisa, Stewart, Elise M., Do-Ha, Dzung, Bax, Monique, Guillemin, Gilles, Vine, Kara L., Hatters, Danny M., Ecroyd, Heath, Dobson, Christopher M., Turner, Bradley J., Ooi, Lezanne, Wilson, Mark R., Cashman, Neil R., Yerbury, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628302/
https://www.ncbi.nlm.nih.gov/pubmed/26520394
http://dx.doi.org/10.1186/s13024-015-0053-4

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