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The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population

BACKGROUND: Visceral adipose tissue, a biologically active fat depot, has been proposed as a reliable marker for visceral adiposity and metabolic abnormalities. Effects of such adiposity on LV diastolic function and dyssynchrony remained largely unknown. METHODS: We assessed pericardial fat (PCF) an...

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Autores principales: Lai, Yau-Huei, Hou, Charles Jia-Yin, Yun, Chun-Ho, Sung, Kuo-Tzu, Su, Cheng-Huang, Wu, Tung-Hsin, Yang, Fei-Shih, Hung, Ta-Chuan, Hung, Chung-Lieh, Bezerra, Hiram G., Yeh, Hung-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628304/
https://www.ncbi.nlm.nih.gov/pubmed/26518903
http://dx.doi.org/10.1186/s12872-015-0136-8
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author Lai, Yau-Huei
Hou, Charles Jia-Yin
Yun, Chun-Ho
Sung, Kuo-Tzu
Su, Cheng-Huang
Wu, Tung-Hsin
Yang, Fei-Shih
Hung, Ta-Chuan
Hung, Chung-Lieh
Bezerra, Hiram G.
Yeh, Hung-I
author_facet Lai, Yau-Huei
Hou, Charles Jia-Yin
Yun, Chun-Ho
Sung, Kuo-Tzu
Su, Cheng-Huang
Wu, Tung-Hsin
Yang, Fei-Shih
Hung, Ta-Chuan
Hung, Chung-Lieh
Bezerra, Hiram G.
Yeh, Hung-I
author_sort Lai, Yau-Huei
collection PubMed
description BACKGROUND: Visceral adipose tissue, a biologically active fat depot, has been proposed as a reliable marker for visceral adiposity and metabolic abnormalities. Effects of such adiposity on LV diastolic function and dyssynchrony remained largely unknown. METHODS: We assessed pericardial fat (PCF) and thoracic peri-aortic fat (TPAF) by three-dimensional (3D) volume-vender multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Echo-derived diastolic parameters and tissue Doppler imaging (TDI) defined mitral annular systolic (S’), early diastolic (E’) velocities as well as LV filling (E/E’) were all obtained. Intra-ventricular systolic (Sys-D) and diastolic (Dias-D) dyssynchrony were assessed by TDI method. RESULTS: A total of 318 asymptomatic subjects (mean age: 53.5 years, 36.8 % female) were eligible in this study. Greater PCF and TPAF were both associated with unfavorable diastolic indices and higher diastolic dyssynchrony (all p < 0.05). These associations remained relatively unchanged in multi-variate models. PCF and TPAF set at 81.68 & 8.11 ml yielded the largest sensitivity and specificity (78.6 and 60 % for PCF, 75 and 66.6 % for TPAF, respectively) in predicting abnormally high LV diastolic dyssynchrony, which was defined as Dias-D≧55 ms. CONCLUSION: Increasing visceral adiposity may be associated with adverse effects on myocardium, primarily featured by worse diastolic function and greater degree of dyssynchrony. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12872-015-0136-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-46283042015-11-01 The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population Lai, Yau-Huei Hou, Charles Jia-Yin Yun, Chun-Ho Sung, Kuo-Tzu Su, Cheng-Huang Wu, Tung-Hsin Yang, Fei-Shih Hung, Ta-Chuan Hung, Chung-Lieh Bezerra, Hiram G. Yeh, Hung-I BMC Cardiovasc Disord Research Article BACKGROUND: Visceral adipose tissue, a biologically active fat depot, has been proposed as a reliable marker for visceral adiposity and metabolic abnormalities. Effects of such adiposity on LV diastolic function and dyssynchrony remained largely unknown. METHODS: We assessed pericardial fat (PCF) and thoracic peri-aortic fat (TPAF) by three-dimensional (3D) volume-vender multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Echo-derived diastolic parameters and tissue Doppler imaging (TDI) defined mitral annular systolic (S’), early diastolic (E’) velocities as well as LV filling (E/E’) were all obtained. Intra-ventricular systolic (Sys-D) and diastolic (Dias-D) dyssynchrony were assessed by TDI method. RESULTS: A total of 318 asymptomatic subjects (mean age: 53.5 years, 36.8 % female) were eligible in this study. Greater PCF and TPAF were both associated with unfavorable diastolic indices and higher diastolic dyssynchrony (all p < 0.05). These associations remained relatively unchanged in multi-variate models. PCF and TPAF set at 81.68 & 8.11 ml yielded the largest sensitivity and specificity (78.6 and 60 % for PCF, 75 and 66.6 % for TPAF, respectively) in predicting abnormally high LV diastolic dyssynchrony, which was defined as Dias-D≧55 ms. CONCLUSION: Increasing visceral adiposity may be associated with adverse effects on myocardium, primarily featured by worse diastolic function and greater degree of dyssynchrony. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12872-015-0136-8) contains supplementary material, which is available to authorized users. BioMed Central 2015-10-30 /pmc/articles/PMC4628304/ /pubmed/26518903 http://dx.doi.org/10.1186/s12872-015-0136-8 Text en © Lai et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lai, Yau-Huei
Hou, Charles Jia-Yin
Yun, Chun-Ho
Sung, Kuo-Tzu
Su, Cheng-Huang
Wu, Tung-Hsin
Yang, Fei-Shih
Hung, Ta-Chuan
Hung, Chung-Lieh
Bezerra, Hiram G.
Yeh, Hung-I
The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title_full The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title_fullStr The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title_full_unstemmed The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title_short The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
title_sort association among mdct-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628304/
https://www.ncbi.nlm.nih.gov/pubmed/26518903
http://dx.doi.org/10.1186/s12872-015-0136-8
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