Roflumilast partially reverses smoke-induced mucociliary dysfunction

BACKGROUND: Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway epithelial cells, PDE4 inhibitors can stimulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by increasing cAMP. Tobacco smoking...

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Detalles Bibliográficos
Autores principales: Schmid, Andreas, Baumlin, Nathalie, Ivonnet, Pedro, Dennis, John S., Campos, Michael, Krick, Stefanie, Salathe, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628339/
https://www.ncbi.nlm.nih.gov/pubmed/26521141
http://dx.doi.org/10.1186/s12931-015-0294-3

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