Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

BACKGROUND: Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer’s disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretion; however, the underlying mechanism is unknown, as IDE has no signal sequence....

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Detalles Bibliográficos
Autores principales: Son, Sung Min, Kang, Seokjo, Choi, Heesun, Mook-Jung, Inhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628355/
https://www.ncbi.nlm.nih.gov/pubmed/26520569
http://dx.doi.org/10.1186/s13024-015-0054-3

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