Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells

BACKGROUND: Mutations in the gene encoding Ubiquilin-2 (UBQLN2) are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). UBQLN2 plays a central role in ubiquitin proteasome system (UPS) and UBQLN2 mutants can form cytoplasmic aggregates in vitro and in vivo. RESULTS: Here...

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Detalles Bibliográficos
Autores principales: Picher-Martel, Vincent, Dutta, Kallol, Phaneuf, Daniel, Sobue, Gen, Julien, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628361/
https://www.ncbi.nlm.nih.gov/pubmed/26521126
http://dx.doi.org/10.1186/s13041-015-0162-6

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