6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

The oxidative pentose phosphate pathway (PPP) contributes to tumor growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and ele...

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Detalles Bibliográficos
Autores principales: Lin, Ruiting, Elf, Shannon, Shan, Changliang, Kang, Hee-Bum, Ji, Quanjiang, Zhou, Lu, Hitosugi, Taro, Zhang, Liang, Zhang, Shuai, Ho Seo, Jae, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, Mitsche, Matthew, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Hurwitz, Selwyn J., Lonial, Sagar, Khoury, Hanna J., Arellano, Martha L., Khuri, Fadlo R., Lee, Benjamin H., Lei, Qunying, Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628560/
https://www.ncbi.nlm.nih.gov/pubmed/26479318
http://dx.doi.org/10.1038/ncb3255

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