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Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis

The levels of soluble intercellular adhesion molecule-1 (sICAM-1) have been reported to increase in patients with idiopathic pulmonary fibrosis. However, the utility of sICAM-1 has not been reported in detail. The aim of this study was to investigate whether sICAM-1 was a useful biomarker for stable...

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Autores principales: Okuda, Ryo, Matsushima, Hidekazu, Aoshiba, Kazutetsu, Oba, Tomohiro, Kawabe, Rie, Honda, Koujiro, Amano, Masako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628606/
https://www.ncbi.nlm.nih.gov/pubmed/26543791
http://dx.doi.org/10.1186/s40064-015-1455-z
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author Okuda, Ryo
Matsushima, Hidekazu
Aoshiba, Kazutetsu
Oba, Tomohiro
Kawabe, Rie
Honda, Koujiro
Amano, Masako
author_facet Okuda, Ryo
Matsushima, Hidekazu
Aoshiba, Kazutetsu
Oba, Tomohiro
Kawabe, Rie
Honda, Koujiro
Amano, Masako
author_sort Okuda, Ryo
collection PubMed
description The levels of soluble intercellular adhesion molecule-1 (sICAM-1) have been reported to increase in patients with idiopathic pulmonary fibrosis. However, the utility of sICAM-1 has not been reported in detail. The aim of this study was to investigate whether sICAM-1 was a useful biomarker for stable idiopathic pulmonary fibrosis (IPF) and early phase of acute exacerbation of IPF. The patients who were diagnosed with IPF between 2013 and 2015 were enrolled. The levels of sICAM-1 and other interstitial pneumonia markers were measured. In this study, 30 patients with stable IPF and 11 patients with acute exacerbation of IPF were collected. Mean sICAM-1 levels were 434 ± 139 ng/mL for the stable phase of IPF, 645 ± 247 ng/mL for early phase of acute exacerbation of IPF, 534 ± 223 ng/mL for connective tissue disease-associated interstitial pneumonia, 221 ± 42 for chronic obstructive pulmonary disease, and 150 ± 32 ng/mL in healthy volunteers. For the stable phase of IPF, sICAM-1 levels correlated with Krebs von den Lungen-6 (KL-6) (r value: 0.41; p value: 0.036). Mean sICAM-1 levels were significantly higher in patients with early phase of acute exacerbation of IPF than with stable phase of IPF (p = 0.0199). Multiple logistic analyses indicated that the predictors for early phase of acute exacerbation of IPF were only sICAM-1 and C-reactive protein (odds ratio: 1.0093; 1.6069). In patients with stable IPF, sICAM-1 levels correlated with KL-6; sICAM-1 might be a predictive indicator for prognosis. In the early phase of acute exacerbation of IPF, sICAM-1 might be more useful for diagnosis than other interstitial pneumonia markers.
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spelling pubmed-46286062015-11-05 Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis Okuda, Ryo Matsushima, Hidekazu Aoshiba, Kazutetsu Oba, Tomohiro Kawabe, Rie Honda, Koujiro Amano, Masako Springerplus Research The levels of soluble intercellular adhesion molecule-1 (sICAM-1) have been reported to increase in patients with idiopathic pulmonary fibrosis. However, the utility of sICAM-1 has not been reported in detail. The aim of this study was to investigate whether sICAM-1 was a useful biomarker for stable idiopathic pulmonary fibrosis (IPF) and early phase of acute exacerbation of IPF. The patients who were diagnosed with IPF between 2013 and 2015 were enrolled. The levels of sICAM-1 and other interstitial pneumonia markers were measured. In this study, 30 patients with stable IPF and 11 patients with acute exacerbation of IPF were collected. Mean sICAM-1 levels were 434 ± 139 ng/mL for the stable phase of IPF, 645 ± 247 ng/mL for early phase of acute exacerbation of IPF, 534 ± 223 ng/mL for connective tissue disease-associated interstitial pneumonia, 221 ± 42 for chronic obstructive pulmonary disease, and 150 ± 32 ng/mL in healthy volunteers. For the stable phase of IPF, sICAM-1 levels correlated with Krebs von den Lungen-6 (KL-6) (r value: 0.41; p value: 0.036). Mean sICAM-1 levels were significantly higher in patients with early phase of acute exacerbation of IPF than with stable phase of IPF (p = 0.0199). Multiple logistic analyses indicated that the predictors for early phase of acute exacerbation of IPF were only sICAM-1 and C-reactive protein (odds ratio: 1.0093; 1.6069). In patients with stable IPF, sICAM-1 levels correlated with KL-6; sICAM-1 might be a predictive indicator for prognosis. In the early phase of acute exacerbation of IPF, sICAM-1 might be more useful for diagnosis than other interstitial pneumonia markers. Springer International Publishing 2015-10-31 /pmc/articles/PMC4628606/ /pubmed/26543791 http://dx.doi.org/10.1186/s40064-015-1455-z Text en © Okuda et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Okuda, Ryo
Matsushima, Hidekazu
Aoshiba, Kazutetsu
Oba, Tomohiro
Kawabe, Rie
Honda, Koujiro
Amano, Masako
Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title_full Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title_fullStr Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title_full_unstemmed Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title_short Soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
title_sort soluble intercellular adhesion molecule-1 for stable and acute phases of idiopathic pulmonary fibrosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628606/
https://www.ncbi.nlm.nih.gov/pubmed/26543791
http://dx.doi.org/10.1186/s40064-015-1455-z
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