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Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma

Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential ind...

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Autores principales: Denk, Stephanie, Wiegner, Rebecca, Hönes, Felix M., Messerer, David A. C., Radermacher, Peter, Weiss, Manfred, Kalbitz, Miriam, Ehrnthaller, Christian, Braumüller, Sonja, McCook, Oscar, Gebhard, Florian, Weckbach, Sebastian, Huber-Lang, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628652/
https://www.ncbi.nlm.nih.gov/pubmed/26556956
http://dx.doi.org/10.1155/2015/463950
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author Denk, Stephanie
Wiegner, Rebecca
Hönes, Felix M.
Messerer, David A. C.
Radermacher, Peter
Weiss, Manfred
Kalbitz, Miriam
Ehrnthaller, Christian
Braumüller, Sonja
McCook, Oscar
Gebhard, Florian
Weckbach, Sebastian
Huber-Lang, Markus
author_facet Denk, Stephanie
Wiegner, Rebecca
Hönes, Felix M.
Messerer, David A. C.
Radermacher, Peter
Weiss, Manfred
Kalbitz, Miriam
Ehrnthaller, Christian
Braumüller, Sonja
McCook, Oscar
Gebhard, Florian
Weckbach, Sebastian
Huber-Lang, Markus
author_sort Denk, Stephanie
collection PubMed
description Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction. The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period. Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure. JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force. Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction. Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score). The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction.
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spelling pubmed-46286522015-11-09 Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma Denk, Stephanie Wiegner, Rebecca Hönes, Felix M. Messerer, David A. C. Radermacher, Peter Weiss, Manfred Kalbitz, Miriam Ehrnthaller, Christian Braumüller, Sonja McCook, Oscar Gebhard, Florian Weckbach, Sebastian Huber-Lang, Markus Mediators Inflamm Research Article Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction. The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period. Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure. JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force. Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction. Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score). The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction. Hindawi Publishing Corporation 2015 2015-10-18 /pmc/articles/PMC4628652/ /pubmed/26556956 http://dx.doi.org/10.1155/2015/463950 Text en Copyright © 2015 Stephanie Denk et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Denk, Stephanie
Wiegner, Rebecca
Hönes, Felix M.
Messerer, David A. C.
Radermacher, Peter
Weiss, Manfred
Kalbitz, Miriam
Ehrnthaller, Christian
Braumüller, Sonja
McCook, Oscar
Gebhard, Florian
Weckbach, Sebastian
Huber-Lang, Markus
Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title_full Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title_fullStr Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title_full_unstemmed Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title_short Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
title_sort early detection of junctional adhesion molecule-1 (jam-1) in the circulation after experimental and clinical polytrauma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628652/
https://www.ncbi.nlm.nih.gov/pubmed/26556956
http://dx.doi.org/10.1155/2015/463950
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