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Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential ind...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628652/ https://www.ncbi.nlm.nih.gov/pubmed/26556956 http://dx.doi.org/10.1155/2015/463950 |
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author | Denk, Stephanie Wiegner, Rebecca Hönes, Felix M. Messerer, David A. C. Radermacher, Peter Weiss, Manfred Kalbitz, Miriam Ehrnthaller, Christian Braumüller, Sonja McCook, Oscar Gebhard, Florian Weckbach, Sebastian Huber-Lang, Markus |
author_facet | Denk, Stephanie Wiegner, Rebecca Hönes, Felix M. Messerer, David A. C. Radermacher, Peter Weiss, Manfred Kalbitz, Miriam Ehrnthaller, Christian Braumüller, Sonja McCook, Oscar Gebhard, Florian Weckbach, Sebastian Huber-Lang, Markus |
author_sort | Denk, Stephanie |
collection | PubMed |
description | Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction. The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period. Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure. JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force. Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction. Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score). The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction. |
format | Online Article Text |
id | pubmed-4628652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46286522015-11-09 Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma Denk, Stephanie Wiegner, Rebecca Hönes, Felix M. Messerer, David A. C. Radermacher, Peter Weiss, Manfred Kalbitz, Miriam Ehrnthaller, Christian Braumüller, Sonja McCook, Oscar Gebhard, Florian Weckbach, Sebastian Huber-Lang, Markus Mediators Inflamm Research Article Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction. However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction. The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period. Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure. JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force. Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction. Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score). The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction. Hindawi Publishing Corporation 2015 2015-10-18 /pmc/articles/PMC4628652/ /pubmed/26556956 http://dx.doi.org/10.1155/2015/463950 Text en Copyright © 2015 Stephanie Denk et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Denk, Stephanie Wiegner, Rebecca Hönes, Felix M. Messerer, David A. C. Radermacher, Peter Weiss, Manfred Kalbitz, Miriam Ehrnthaller, Christian Braumüller, Sonja McCook, Oscar Gebhard, Florian Weckbach, Sebastian Huber-Lang, Markus Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title | Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title_full | Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title_fullStr | Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title_full_unstemmed | Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title_short | Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma |
title_sort | early detection of junctional adhesion molecule-1 (jam-1) in the circulation after experimental and clinical polytrauma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628652/ https://www.ncbi.nlm.nih.gov/pubmed/26556956 http://dx.doi.org/10.1155/2015/463950 |
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