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Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts

Emerging evidence suggests a role for sphingosine-1-phosphate (S1P) in various aspects of rheumatoid arthritis (RA) pathogenesis. In this study we compared the effect of chemical hypoxia induced by cobalt chloride (CoCl(2)) on the expression of S1P metabolic enzymes and cytokine/chemokine secretion...

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Detalles Bibliográficos
Autores principales:	Zhao, Chenqi, Moreno-Nieves, Uriel, Di Battista, John A., Fernandes, Maria J., Touaibia, Mohamed, Bourgoin, Sylvain G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628658/ https://www.ncbi.nlm.nih.gov/pubmed/26556954 http://dx.doi.org/10.1155/2015/436525

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