Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant

Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) proph...

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Detalles Bibliográficos
Autores principales: Augustyn, Alexander, Lisa Alattar, Mona, Naina, Harris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628682/
https://www.ncbi.nlm.nih.gov/pubmed/26557399
http://dx.doi.org/10.1155/2015/619473
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author Augustyn, Alexander
Lisa Alattar, Mona
Naina, Harris
author_facet Augustyn, Alexander
Lisa Alattar, Mona
Naina, Harris
author_sort Augustyn, Alexander
collection PubMed
description Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients.
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spelling pubmed-46286822015-11-09 Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant Augustyn, Alexander Lisa Alattar, Mona Naina, Harris Case Rep Oncol Med Case Report Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients. Hindawi Publishing Corporation 2015 2015-10-18 /pmc/articles/PMC4628682/ /pubmed/26557399 http://dx.doi.org/10.1155/2015/619473 Text en Copyright © 2015 Alexander Augustyn et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Augustyn, Alexander
Lisa Alattar, Mona
Naina, Harris
Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_full Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_fullStr Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_full_unstemmed Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_short Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_sort rhabdomyolysis due to trimethoprim-sulfamethoxazole administration following a hematopoietic stem cell transplant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628682/
https://www.ncbi.nlm.nih.gov/pubmed/26557399
http://dx.doi.org/10.1155/2015/619473
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AT nainaharris rhabdomyolysisduetotrimethoprimsulfamethoxazoleadministrationfollowingahematopoieticstemcelltransplant

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