New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond

The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduct...

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Detalles Bibliográficos
Autores principales: Keniry, Megan, Dearth, Robert K., Persans, Michael, Parsons, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Applied Systems srl 2014
Materias:
Perspective Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629104/
https://www.ncbi.nlm.nih.gov/pubmed/26539561
http://dx.doi.org/10.15190/d.2014.7
Descripción
Sumario:The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction.

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