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New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond

The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduct...

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Detalles Bibliográficos
Autores principales: Keniry, Megan, Dearth, Robert K., Persans, Michael, Parsons, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Applied Systems srl 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629104/
https://www.ncbi.nlm.nih.gov/pubmed/26539561
http://dx.doi.org/10.15190/d.2014.7
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author Keniry, Megan
Dearth, Robert K.
Persans, Michael
Parsons, Ramon
author_facet Keniry, Megan
Dearth, Robert K.
Persans, Michael
Parsons, Ramon
author_sort Keniry, Megan
collection PubMed
description The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction.
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spelling pubmed-46291042015-11-02 New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond Keniry, Megan Dearth, Robert K. Persans, Michael Parsons, Ramon Discoveries (Craiova) Perspective Article The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction. Applied Systems srl 2014-06-30 /pmc/articles/PMC4629104/ /pubmed/26539561 http://dx.doi.org/10.15190/d.2014.7 Text en Copyright: © 2014, Keniry et al. and Applied Systems http://creativecommons.org/licenses/by/4.0/ This article is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective Article
Keniry, Megan
Dearth, Robert K.
Persans, Michael
Parsons, Ramon
New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title_full New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title_fullStr New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title_full_unstemmed New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title_short New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
title_sort new frontiers for the nfil3 bzip transcription factor in cancer, metabolism and beyond
topic Perspective Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629104/
https://www.ncbi.nlm.nih.gov/pubmed/26539561
http://dx.doi.org/10.15190/d.2014.7
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