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New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond
The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduct...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Applied Systems srl
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629104/ https://www.ncbi.nlm.nih.gov/pubmed/26539561 http://dx.doi.org/10.15190/d.2014.7 |
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author | Keniry, Megan Dearth, Robert K. Persans, Michael Parsons, Ramon |
author_facet | Keniry, Megan Dearth, Robert K. Persans, Michael Parsons, Ramon |
author_sort | Keniry, Megan |
collection | PubMed |
description | The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction. |
format | Online Article Text |
id | pubmed-4629104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Applied Systems srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-46291042015-11-02 New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond Keniry, Megan Dearth, Robert K. Persans, Michael Parsons, Ramon Discoveries (Craiova) Perspective Article The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction. Applied Systems srl 2014-06-30 /pmc/articles/PMC4629104/ /pubmed/26539561 http://dx.doi.org/10.15190/d.2014.7 Text en Copyright: © 2014, Keniry et al. and Applied Systems http://creativecommons.org/licenses/by/4.0/ This article is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Perspective Article Keniry, Megan Dearth, Robert K. Persans, Michael Parsons, Ramon New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title | New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title_full | New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title_fullStr | New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title_full_unstemmed | New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title_short | New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond |
title_sort | new frontiers for the nfil3 bzip transcription factor in cancer, metabolism and beyond |
topic | Perspective Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629104/ https://www.ncbi.nlm.nih.gov/pubmed/26539561 http://dx.doi.org/10.15190/d.2014.7 |
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