Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Prenylated proteins play key roles in several human diseases including cancer, atherosclerosis and Alzheimer’s disease. KRAS4b, which is frequently mutated in pancreatic, colon and lung cancers, is processed by farnesylation, proteolytic cleavage and carboxymethylation at the C-terminus. Plasma memb...

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Detalles Bibliográficos
Autores principales: Gillette, William K., Esposito, Dominic, Abreu Blanco, Maria, Alexander, Patrick, Bindu, Lakshman, Bittner, Cammi, Chertov, Oleg, Frank, Peter H., Grose, Carissa, Jones, Jane E., Meng, Zhaojing, Perkins, Shelley, Van, Que, Ghirlando, Rodolfo, Fivash, Matthew, Nissley, Dwight V., McCormick, Frank, Holderfield, Matthew, Stephen, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629113/
https://www.ncbi.nlm.nih.gov/pubmed/26522388
http://dx.doi.org/10.1038/srep15916

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