Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established b...

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Detalles Bibliográficos
Autores principales: Zhou, Zhenfang, Wang, Xin, Zhang, Hui, Sun, Jingya, Zheng, Linghui, Liu, Hongchun, Wang, Jidong, Shen, Aijun, Geng, Meiyu, Guo, Yuewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629120/
https://www.ncbi.nlm.nih.gov/pubmed/26579426
http://dx.doi.org/10.1016/j.apsb.2014.11.001
Descripción
Sumario:A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K(α) radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively.

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