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Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94
A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established b...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629120/ https://www.ncbi.nlm.nih.gov/pubmed/26579426 http://dx.doi.org/10.1016/j.apsb.2014.11.001 |
| _version_ | 1782398532663115776 |
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| author | Zhou, Zhenfang Wang, Xin Zhang, Hui Sun, Jingya Zheng, Linghui Liu, Hongchun Wang, Jidong Shen, Aijun Geng, Meiyu Guo, Yuewei |
| author_facet | Zhou, Zhenfang Wang, Xin Zhang, Hui Sun, Jingya Zheng, Linghui Liu, Hongchun Wang, Jidong Shen, Aijun Geng, Meiyu Guo, Yuewei |
| author_sort | Zhou, Zhenfang |
| collection | PubMed |
| description | A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K(α) radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively. |
| format | Online Article Text |
| id | pubmed-4629120 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46291202015-11-17 Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 Zhou, Zhenfang Wang, Xin Zhang, Hui Sun, Jingya Zheng, Linghui Liu, Hongchun Wang, Jidong Shen, Aijun Geng, Meiyu Guo, Yuewei Acta Pharm Sin B Original Article A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K(α) radiation (λ=0.71073 Å) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60, K-562, and Ramos cells with average IC(50) values of 7.7, 7.0, and 16.5 nmol/L, respectively. Elsevier 2015-01 2015-01-07 /pmc/articles/PMC4629120/ /pubmed/26579426 http://dx.doi.org/10.1016/j.apsb.2014.11.001 Text en © 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| spellingShingle | Original Article Zhou, Zhenfang Wang, Xin Zhang, Hui Sun, Jingya Zheng, Linghui Liu, Hongchun Wang, Jidong Shen, Aijun Geng, Meiyu Guo, Yuewei Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title_full | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title_fullStr | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title_full_unstemmed | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title_short | Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94 |
| title_sort | chromopeptide a, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium chromobacterium sp. hs-13-94 |
| topic | Original Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629120/ https://www.ncbi.nlm.nih.gov/pubmed/26579426 http://dx.doi.org/10.1016/j.apsb.2014.11.001 |
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