Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53

Necrosis, unregulated cell death, is characterized by plasma membrane rupture as well as nuclear and cellular swelling. However, it has recently been reported that necrosis is a regulated form of cell death mediated by poly-(ADP-ribose) polymerase 1 (PARP1). PARP1 is thought to mediate necrosis by i...

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Detalles Bibliográficos
Autores principales: Shin, Hyeon-Jun, Kwon, Hyuk-Kwon, Lee, Jae-Hyeok, Gui, Xiangai, Achek, Asma, Kim, Jae-Ho, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629133/
https://www.ncbi.nlm.nih.gov/pubmed/26522181
http://dx.doi.org/10.1038/srep15798

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