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Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload

Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-deriv...

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Detalles Bibliográficos
Autores principales:	Yano, Masamichi, Akazawa, Hiroshi, Oka, Toru, Yabumoto, Chizuru, Kudo-Sakamoto, Yoko, Kamo, Takehiro, Shimizu, Yu, Yagi, Hiroki, Naito, Atsuhiko T., Lee, Jong-Kook, Suzuki, Jun-ichi, Sakata, Yasushi, Komuro, Issei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629142/ https://www.ncbi.nlm.nih.gov/pubmed/26522369 http://dx.doi.org/10.1038/srep15857

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