Bub1 is required for maintaining cancer stem cells in breast cancer cell lines

Breast cancer is a leading cause of death among women worldwide due to therapeutic resistance and cancer recurrence. Cancer stem cells are believed to be responsible for resistance and recurrence. Many efforts to overcome resistance and recurrence by regulating cancer stem cells are ongoing. Bub1 (B...

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Autores principales: Han, Jeong Yoon, Han, Yu Kyeong, Park, Ga-Young, Kim, Sung Dae, Kim, Joong Sun, Jo, Wol Soon, Geun Lee, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629164/
https://www.ncbi.nlm.nih.gov/pubmed/26522589
http://dx.doi.org/10.1038/srep15993
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author Han, Jeong Yoon
Han, Yu Kyeong
Park, Ga-Young
Kim, Sung Dae
Kim, Joong Sun
Jo, Wol Soon
Geun Lee, Chang
author_facet Han, Jeong Yoon
Han, Yu Kyeong
Park, Ga-Young
Kim, Sung Dae
Kim, Joong Sun
Jo, Wol Soon
Geun Lee, Chang
author_sort Han, Jeong Yoon
collection PubMed
description Breast cancer is a leading cause of death among women worldwide due to therapeutic resistance and cancer recurrence. Cancer stem cells are believed to be responsible for resistance and recurrence. Many efforts to overcome resistance and recurrence by regulating cancer stem cells are ongoing. Bub1 (Budding uninhibited by benzimidazoles 1) is a mitotic checkpoint serine/threonine kinase that plays an important role in chromosome segregation. Bub1 expression is correlated with a poor clinical prognosis in patients with breast cancer. We identified that depleting Bub1 using shRNAs reduces cancer stem cell potential of the MDA-MB-231 breast cancer cell line, resulting in inhibited formation of xenografts in immunocompromised mice. These results suggest that Bub1 may be associated with cancer stem cell potential and could be a target for developing anti-breast cancer stem cell therapies.
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spelling pubmed-46291642015-11-05 Bub1 is required for maintaining cancer stem cells in breast cancer cell lines Han, Jeong Yoon Han, Yu Kyeong Park, Ga-Young Kim, Sung Dae Kim, Joong Sun Jo, Wol Soon Geun Lee, Chang Sci Rep Article Breast cancer is a leading cause of death among women worldwide due to therapeutic resistance and cancer recurrence. Cancer stem cells are believed to be responsible for resistance and recurrence. Many efforts to overcome resistance and recurrence by regulating cancer stem cells are ongoing. Bub1 (Budding uninhibited by benzimidazoles 1) is a mitotic checkpoint serine/threonine kinase that plays an important role in chromosome segregation. Bub1 expression is correlated with a poor clinical prognosis in patients with breast cancer. We identified that depleting Bub1 using shRNAs reduces cancer stem cell potential of the MDA-MB-231 breast cancer cell line, resulting in inhibited formation of xenografts in immunocompromised mice. These results suggest that Bub1 may be associated with cancer stem cell potential and could be a target for developing anti-breast cancer stem cell therapies. Nature Publishing Group 2015-11-02 /pmc/articles/PMC4629164/ /pubmed/26522589 http://dx.doi.org/10.1038/srep15993 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Han, Jeong Yoon
Han, Yu Kyeong
Park, Ga-Young
Kim, Sung Dae
Kim, Joong Sun
Jo, Wol Soon
Geun Lee, Chang
Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title_full Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title_fullStr Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title_full_unstemmed Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title_short Bub1 is required for maintaining cancer stem cells in breast cancer cell lines
title_sort bub1 is required for maintaining cancer stem cells in breast cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629164/
https://www.ncbi.nlm.nih.gov/pubmed/26522589
http://dx.doi.org/10.1038/srep15993
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