DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth....

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Detalles Bibliográficos
Autores principales: Sha, Mingquan, Mao, Genxiang, Wang, Guofu, Chen, Yufeng, Wu, Xiaojian, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629229/
https://www.ncbi.nlm.nih.gov/pubmed/26579445
http://dx.doi.org/10.1016/j.apsb.2015.01.011
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author Sha, Mingquan
Mao, Genxiang
Wang, Guofu
Chen, Yufeng
Wu, Xiaojian
Wang, Zhen
author_facet Sha, Mingquan
Mao, Genxiang
Wang, Guofu
Chen, Yufeng
Wu, Xiaojian
Wang, Zhen
author_sort Sha, Mingquan
collection PubMed
description EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.
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spelling pubmed-46292292015-11-17 DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis Sha, Mingquan Mao, Genxiang Wang, Guofu Chen, Yufeng Wu, Xiaojian Wang, Zhen Acta Pharm Sin B Original Article EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth. However, the anti-cancer role of DZNep in colon cancer cells has been rarely studied. In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells. Elsevier 2015-05 2015-04-07 /pmc/articles/PMC4629229/ /pubmed/26579445 http://dx.doi.org/10.1016/j.apsb.2015.01.011 Text en © 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Sha, Mingquan
Mao, Genxiang
Wang, Guofu
Chen, Yufeng
Wu, Xiaojian
Wang, Zhen
DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title_full DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title_fullStr DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title_full_unstemmed DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title_short DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
title_sort dznep inhibits the proliferation of colon cancer hct116 cells by inducing senescence and apoptosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629229/
https://www.ncbi.nlm.nih.gov/pubmed/26579445
http://dx.doi.org/10.1016/j.apsb.2015.01.011
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