DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth....

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Detalles Bibliográficos
Autores principales: Sha, Mingquan, Mao, Genxiang, Wang, Guofu, Chen, Yufeng, Wu, Xiaojian, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629229/
https://www.ncbi.nlm.nih.gov/pubmed/26579445
http://dx.doi.org/10.1016/j.apsb.2015.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629229/
https://www.ncbi.nlm.nih.gov/pubmed/26579445
http://dx.doi.org/10.1016/j.apsb.2015.01.011

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