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Site-specific PEGylation of lidamycin and its antitumor activity

In this study, N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein (rLDP) of lidamycin (LDM) was prepared using a polyethyleneglycol (PEG) derivative (M(w) 20 kDa) through a reactive terminal aldehyde group under weak acidic conditions (pH 5.5). The biochemical propertie...

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Detalles Bibliográficos
Autores principales:	Li, Liang, Shang, Boyang, Hu, Lei, Shao, Rongguang, Zhen, Yongsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629235/ https://www.ncbi.nlm.nih.gov/pubmed/26579455 http://dx.doi.org/10.1016/j.apsb.2015.03.006

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