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Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies

BACKGROUND: The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of extrahepatic biliary tree stone in the incidence of ICC is controversial. In the...

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Autores principales: Cai, Hao, Kong, Wen-Tao, Chen, Chao-Bo, Shi, Guo-Ming, Huang, Cheng, Shen, Ying-Hao, Sun, Hui-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629290/
https://www.ncbi.nlm.nih.gov/pubmed/26526500
http://dx.doi.org/10.1186/s12885-015-1870-0
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author Cai, Hao
Kong, Wen-Tao
Chen, Chao-Bo
Shi, Guo-Ming
Huang, Cheng
Shen, Ying-Hao
Sun, Hui-Chuan
author_facet Cai, Hao
Kong, Wen-Tao
Chen, Chao-Bo
Shi, Guo-Ming
Huang, Cheng
Shen, Ying-Hao
Sun, Hui-Chuan
author_sort Cai, Hao
collection PubMed
description BACKGROUND: The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of extrahepatic biliary tree stone in the incidence of ICC is controversial. In the present study we aim to evaluate the association between pre-existing choledocholithiasis and cholecystolithiasis and the risk of ICC. METHODS: PubMed, Embase, and Web of Science were searched to identify cohort and case–control studies on the association between choledocholithiasis or cholecystolithiasis and the risk of ICC. Studies that met the inclusion criteria were subjected to a meta-analysis performed with Stata statistical software. Either a fixed or random effect model was used, depending on the heterogeneity within the studies. Egger’s test was performed to assess publication bias. RESULTS: Seven case–control studies met our inclusion criteria. Of the 123,771 participants, 4763 (3.85 %) were patients with ICC, and 119,008 were tumor-free controls. The presence of pre-existing bile duct stones (choledocholithiasis alone or choledocholithiasis accompanied by hepatolithiasis) was associated with the risk of ICC (odds ratio [OR] 17.64, 95 % confidence interval [CI] 11.14–27.95). Even the presence of choledocholithiasis alone (in the absence of hepatolithiasis) was associated with a high risk of ICC (OR 11.79, 95 % CI 4.17–33.35). Cholecystolithiasis may possibly contributed to the incidence of ICC (OR 2.00, 95 % CI 1.16–3.42), with large heterogeneity within studies (I(2) = 78.5 %). CONCLUSIONS: Bile duct stones including choledocholithiasis are important risk factors for ICC. Careful surveillance of patients with extrahepatic biliary tree stone should be considered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1870-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-46292902015-11-03 Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies Cai, Hao Kong, Wen-Tao Chen, Chao-Bo Shi, Guo-Ming Huang, Cheng Shen, Ying-Hao Sun, Hui-Chuan BMC Cancer Research Article BACKGROUND: The etiological factor for intrahepatic cholangiocarcinoma (ICC) is not clear. Although it has been widely accepted that intrahepatic biliary tree stone is associated with increased risk of ICC, the role of extrahepatic biliary tree stone in the incidence of ICC is controversial. In the present study we aim to evaluate the association between pre-existing choledocholithiasis and cholecystolithiasis and the risk of ICC. METHODS: PubMed, Embase, and Web of Science were searched to identify cohort and case–control studies on the association between choledocholithiasis or cholecystolithiasis and the risk of ICC. Studies that met the inclusion criteria were subjected to a meta-analysis performed with Stata statistical software. Either a fixed or random effect model was used, depending on the heterogeneity within the studies. Egger’s test was performed to assess publication bias. RESULTS: Seven case–control studies met our inclusion criteria. Of the 123,771 participants, 4763 (3.85 %) were patients with ICC, and 119,008 were tumor-free controls. The presence of pre-existing bile duct stones (choledocholithiasis alone or choledocholithiasis accompanied by hepatolithiasis) was associated with the risk of ICC (odds ratio [OR] 17.64, 95 % confidence interval [CI] 11.14–27.95). Even the presence of choledocholithiasis alone (in the absence of hepatolithiasis) was associated with a high risk of ICC (OR 11.79, 95 % CI 4.17–33.35). Cholecystolithiasis may possibly contributed to the incidence of ICC (OR 2.00, 95 % CI 1.16–3.42), with large heterogeneity within studies (I(2) = 78.5 %). CONCLUSIONS: Bile duct stones including choledocholithiasis are important risk factors for ICC. Careful surveillance of patients with extrahepatic biliary tree stone should be considered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1870-0) contains supplementary material, which is available to authorized users. BioMed Central 2015-11-02 /pmc/articles/PMC4629290/ /pubmed/26526500 http://dx.doi.org/10.1186/s12885-015-1870-0 Text en © Cai et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Cai, Hao
Kong, Wen-Tao
Chen, Chao-Bo
Shi, Guo-Ming
Huang, Cheng
Shen, Ying-Hao
Sun, Hui-Chuan
Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title_full Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title_fullStr Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title_full_unstemmed Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title_short Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
title_sort cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629290/
https://www.ncbi.nlm.nih.gov/pubmed/26526500
http://dx.doi.org/10.1186/s12885-015-1870-0
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