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Current developments in pharmacological therapeutics for chronic constipation

Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic...

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Detalles Bibliográficos
Autores principales: Jiang, Chunhuan, Xu, Qinglong, Wen, Xiaoan, Sun, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629408/
https://www.ncbi.nlm.nih.gov/pubmed/26579459
http://dx.doi.org/10.1016/j.apsb.2015.05.006
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author Jiang, Chunhuan
Xu, Qinglong
Wen, Xiaoan
Sun, Hongbin
author_facet Jiang, Chunhuan
Xu, Qinglong
Wen, Xiaoan
Sun, Hongbin
author_sort Jiang, Chunhuan
collection PubMed
description Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT(4) receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field.
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spelling pubmed-46294082015-11-17 Current developments in pharmacological therapeutics for chronic constipation Jiang, Chunhuan Xu, Qinglong Wen, Xiaoan Sun, Hongbin Acta Pharm Sin B Review Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT(4) receptor modulators velusetrag and naronapride, the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. Elsevier 2015-07 2015-06-06 /pmc/articles/PMC4629408/ /pubmed/26579459 http://dx.doi.org/10.1016/j.apsb.2015.05.006 Text en © 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Jiang, Chunhuan
Xu, Qinglong
Wen, Xiaoan
Sun, Hongbin
Current developments in pharmacological therapeutics for chronic constipation
title Current developments in pharmacological therapeutics for chronic constipation
title_full Current developments in pharmacological therapeutics for chronic constipation
title_fullStr Current developments in pharmacological therapeutics for chronic constipation
title_full_unstemmed Current developments in pharmacological therapeutics for chronic constipation
title_short Current developments in pharmacological therapeutics for chronic constipation
title_sort current developments in pharmacological therapeutics for chronic constipation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629408/
https://www.ncbi.nlm.nih.gov/pubmed/26579459
http://dx.doi.org/10.1016/j.apsb.2015.05.006
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