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Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...
Autores principales: | Abed, Dhulfiqar Ali, Goldstein, Melanie, Albanyan, Haifa, Jin, Huijuan, Hu, Longqin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629420/ https://www.ncbi.nlm.nih.gov/pubmed/26579458 http://dx.doi.org/10.1016/j.apsb.2015.05.008 |
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