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Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes...

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Detalles Bibliográficos
Autores principales: Abed, Dhulfiqar Ali, Goldstein, Melanie, Albanyan, Haifa, Jin, Huijuan, Hu, Longqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629420/
https://www.ncbi.nlm.nih.gov/pubmed/26579458
http://dx.doi.org/10.1016/j.apsb.2015.05.008

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