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Expression of Bcl-2 in canine osteosarcoma
Osteosarcoma (OS) is the most common primary malignancy of bone. It is responsible for 80-85% of the primary bone tumors affecting dogs and it is characterized by aggressive and invasive behavior, with a high metastatic potential. Several studies on cancer and related tumorigenesis, show an involvem...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629559/ https://www.ncbi.nlm.nih.gov/pubmed/26623359 |
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author | Piro, F. Leonardi, L. |
author_facet | Piro, F. Leonardi, L. |
author_sort | Piro, F. |
collection | PubMed |
description | Osteosarcoma (OS) is the most common primary malignancy of bone. It is responsible for 80-85% of the primary bone tumors affecting dogs and it is characterized by aggressive and invasive behavior, with a high metastatic potential. Several studies on cancer and related tumorigenesis, show an involvement of the mechanisms of programmed cell death and cell survival. Many signals seem to be involved in the related mechanism of autophagy and in particular, our interest is focused on the expression of a family of Bcl-2 that seems to be involved either in the control of biomolecular mechanisms like autophagy and apoptosis. In this study we investigated the expression of Bcl-2 in different cases of spontaneous canine osteosarcoma and the related preliminary results are described. We found Bcl-2 activity was increased in OS tissue compared to normal bone tissue. These results suggested that Bcl-2 activity may play an important role in the formation of OS and as a diagnostic for neoplastic activity. However, further research is needed to confirm the role of Bcl-2 activity in OS in canines. |
format | Online Article Text |
id | pubmed-4629559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-46295592015-11-30 Expression of Bcl-2 in canine osteosarcoma Piro, F. Leonardi, L. Open Vet J Original Article Osteosarcoma (OS) is the most common primary malignancy of bone. It is responsible for 80-85% of the primary bone tumors affecting dogs and it is characterized by aggressive and invasive behavior, with a high metastatic potential. Several studies on cancer and related tumorigenesis, show an involvement of the mechanisms of programmed cell death and cell survival. Many signals seem to be involved in the related mechanism of autophagy and in particular, our interest is focused on the expression of a family of Bcl-2 that seems to be involved either in the control of biomolecular mechanisms like autophagy and apoptosis. In this study we investigated the expression of Bcl-2 in different cases of spontaneous canine osteosarcoma and the related preliminary results are described. We found Bcl-2 activity was increased in OS tissue compared to normal bone tissue. These results suggested that Bcl-2 activity may play an important role in the formation of OS and as a diagnostic for neoplastic activity. However, further research is needed to confirm the role of Bcl-2 activity in OS in canines. Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology 2015 2015-03-19 /pmc/articles/PMC4629559/ /pubmed/26623359 Text en Copyright: © Open Veterinary Journal http://creativecommons.org/licenses/by-nc-sa/4.0 Open Veterinary Journal is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Original Article Piro, F. Leonardi, L. Expression of Bcl-2 in canine osteosarcoma |
title | Expression of Bcl-2 in canine osteosarcoma |
title_full | Expression of Bcl-2 in canine osteosarcoma |
title_fullStr | Expression of Bcl-2 in canine osteosarcoma |
title_full_unstemmed | Expression of Bcl-2 in canine osteosarcoma |
title_short | Expression of Bcl-2 in canine osteosarcoma |
title_sort | expression of bcl-2 in canine osteosarcoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629559/ https://www.ncbi.nlm.nih.gov/pubmed/26623359 |
work_keys_str_mv | AT pirof expressionofbcl2incanineosteosarcoma AT leonardil expressionofbcl2incanineosteosarcoma |