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Exploring the origins of asthma: Lessons from twin studies
This thesis explores the contribution of twin studies, particularly those studies originating from the Danish Twin Registry, to the understanding of the aetiology of asthma. First, it is explored how twin studies have established the contribution of genetic and environmental factors to the variation...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Co-Action Publishing
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629771/ https://www.ncbi.nlm.nih.gov/pubmed/26557247 http://dx.doi.org/10.3402/ecrj.v1.25535 |
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author | Thomsen, Simon Francis |
author_facet | Thomsen, Simon Francis |
author_sort | Thomsen, Simon Francis |
collection | PubMed |
description | This thesis explores the contribution of twin studies, particularly those studies originating from the Danish Twin Registry, to the understanding of the aetiology of asthma. First, it is explored how twin studies have established the contribution of genetic and environmental factors to the variation in the susceptibility to asthma, and to the variation in several aspects of the clinical expression of the disease such as its age at onset, its symptomatology, its intermediate phenotypes, and its relationship with other atopic diseases. Next, it is explored how twin studies have corroborated theories explaining asthma's recent increase in prevalence, and last, how these fit with the explanations of the epidemiological trends in other common chronic diseases of modernity. |
format | Online Article Text |
id | pubmed-4629771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-46297712015-11-09 Exploring the origins of asthma: Lessons from twin studies Thomsen, Simon Francis Eur Clin Respir J Supplement 1, 2014 This thesis explores the contribution of twin studies, particularly those studies originating from the Danish Twin Registry, to the understanding of the aetiology of asthma. First, it is explored how twin studies have established the contribution of genetic and environmental factors to the variation in the susceptibility to asthma, and to the variation in several aspects of the clinical expression of the disease such as its age at onset, its symptomatology, its intermediate phenotypes, and its relationship with other atopic diseases. Next, it is explored how twin studies have corroborated theories explaining asthma's recent increase in prevalence, and last, how these fit with the explanations of the epidemiological trends in other common chronic diseases of modernity. Co-Action Publishing 2014-09-01 /pmc/articles/PMC4629771/ /pubmed/26557247 http://dx.doi.org/10.3402/ecrj.v1.25535 Text en © 2014 Simon Francis Thomsen http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. |
spellingShingle | Supplement 1, 2014 Thomsen, Simon Francis Exploring the origins of asthma: Lessons from twin studies |
title | Exploring the origins of asthma: Lessons from twin studies |
title_full | Exploring the origins of asthma: Lessons from twin studies |
title_fullStr | Exploring the origins of asthma: Lessons from twin studies |
title_full_unstemmed | Exploring the origins of asthma: Lessons from twin studies |
title_short | Exploring the origins of asthma: Lessons from twin studies |
title_sort | exploring the origins of asthma: lessons from twin studies |
topic | Supplement 1, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629771/ https://www.ncbi.nlm.nih.gov/pubmed/26557247 http://dx.doi.org/10.3402/ecrj.v1.25535 |
work_keys_str_mv | AT thomsensimonfrancis exploringtheoriginsofasthmalessonsfromtwinstudies |