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A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amo...

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Autores principales: Sherrell, Darren A., Foster, Andrew J., Hudson, Lee, Nutter, Brian, O’Hea, James, Nelson, Silke, Paré-Labrosse, Olivier, Oghbaey, Saeed, Miller, R. J. Dwayne, Owen, Robin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629865/
https://www.ncbi.nlm.nih.gov/pubmed/26524301
http://dx.doi.org/10.1107/S1600577515016938
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author Sherrell, Darren A.
Foster, Andrew J.
Hudson, Lee
Nutter, Brian
O’Hea, James
Nelson, Silke
Paré-Labrosse, Olivier
Oghbaey, Saeed
Miller, R. J. Dwayne
Owen, Robin L.
author_facet Sherrell, Darren A.
Foster, Andrew J.
Hudson, Lee
Nutter, Brian
O’Hea, James
Nelson, Silke
Paré-Labrosse, Olivier
Oghbaey, Saeed
Miller, R. J. Dwayne
Owen, Robin L.
author_sort Sherrell, Darren A.
collection PubMed
description The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.
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spelling pubmed-46298652015-11-20 A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources Sherrell, Darren A. Foster, Andrew J. Hudson, Lee Nutter, Brian O’Hea, James Nelson, Silke Paré-Labrosse, Olivier Oghbaey, Saeed Miller, R. J. Dwayne Owen, Robin L. J Synchrotron Radiat Research Papers The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply. International Union of Crystallography 2015-10-06 /pmc/articles/PMC4629865/ /pubmed/26524301 http://dx.doi.org/10.1107/S1600577515016938 Text en © Darren A. Sherrell et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Papers
Sherrell, Darren A.
Foster, Andrew J.
Hudson, Lee
Nutter, Brian
O’Hea, James
Nelson, Silke
Paré-Labrosse, Olivier
Oghbaey, Saeed
Miller, R. J. Dwayne
Owen, Robin L.
A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title_full A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title_fullStr A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title_full_unstemmed A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title_short A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
title_sort modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at fel and synchrotron sources
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629865/
https://www.ncbi.nlm.nih.gov/pubmed/26524301
http://dx.doi.org/10.1107/S1600577515016938
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