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A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources
The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629865/ https://www.ncbi.nlm.nih.gov/pubmed/26524301 http://dx.doi.org/10.1107/S1600577515016938 |
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author | Sherrell, Darren A. Foster, Andrew J. Hudson, Lee Nutter, Brian O’Hea, James Nelson, Silke Paré-Labrosse, Olivier Oghbaey, Saeed Miller, R. J. Dwayne Owen, Robin L. |
author_facet | Sherrell, Darren A. Foster, Andrew J. Hudson, Lee Nutter, Brian O’Hea, James Nelson, Silke Paré-Labrosse, Olivier Oghbaey, Saeed Miller, R. J. Dwayne Owen, Robin L. |
author_sort | Sherrell, Darren A. |
collection | PubMed |
description | The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply. |
format | Online Article Text |
id | pubmed-4629865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-46298652015-11-20 A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources Sherrell, Darren A. Foster, Andrew J. Hudson, Lee Nutter, Brian O’Hea, James Nelson, Silke Paré-Labrosse, Olivier Oghbaey, Saeed Miller, R. J. Dwayne Owen, Robin L. J Synchrotron Radiat Research Papers The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply. International Union of Crystallography 2015-10-06 /pmc/articles/PMC4629865/ /pubmed/26524301 http://dx.doi.org/10.1107/S1600577515016938 Text en © Darren A. Sherrell et al. 2015 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Research Papers Sherrell, Darren A. Foster, Andrew J. Hudson, Lee Nutter, Brian O’Hea, James Nelson, Silke Paré-Labrosse, Olivier Oghbaey, Saeed Miller, R. J. Dwayne Owen, Robin L. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title | A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title_full | A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title_fullStr | A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title_full_unstemmed | A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title_short | A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources |
title_sort | modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at fel and synchrotron sources |
topic | Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629865/ https://www.ncbi.nlm.nih.gov/pubmed/26524301 http://dx.doi.org/10.1107/S1600577515016938 |
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