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Cerebral small vessel disease and Alzheimer’s disease

Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s dise...

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Autores principales: Cai, Zhiyou, Wang, Chuanling, He, Wenbo, Tu, Hanjun, Tang, Zhengang, Xiao, Ming, Yan, Liang-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629951/
https://www.ncbi.nlm.nih.gov/pubmed/26604717
http://dx.doi.org/10.2147/CIA.S90871
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author Cai, Zhiyou
Wang, Chuanling
He, Wenbo
Tu, Hanjun
Tang, Zhengang
Xiao, Ming
Yan, Liang-Jun
author_facet Cai, Zhiyou
Wang, Chuanling
He, Wenbo
Tu, Hanjun
Tang, Zhengang
Xiao, Ming
Yan, Liang-Jun
author_sort Cai, Zhiyou
collection PubMed
description Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer’s disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD.
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spelling pubmed-46299512015-11-24 Cerebral small vessel disease and Alzheimer’s disease Cai, Zhiyou Wang, Chuanling He, Wenbo Tu, Hanjun Tang, Zhengang Xiao, Ming Yan, Liang-Jun Clin Interv Aging Review Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer’s disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD. Dove Medical Press 2015-10-23 /pmc/articles/PMC4629951/ /pubmed/26604717 http://dx.doi.org/10.2147/CIA.S90871 Text en © 2015 Cai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Cai, Zhiyou
Wang, Chuanling
He, Wenbo
Tu, Hanjun
Tang, Zhengang
Xiao, Ming
Yan, Liang-Jun
Cerebral small vessel disease and Alzheimer’s disease
title Cerebral small vessel disease and Alzheimer’s disease
title_full Cerebral small vessel disease and Alzheimer’s disease
title_fullStr Cerebral small vessel disease and Alzheimer’s disease
title_full_unstemmed Cerebral small vessel disease and Alzheimer’s disease
title_short Cerebral small vessel disease and Alzheimer’s disease
title_sort cerebral small vessel disease and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629951/
https://www.ncbi.nlm.nih.gov/pubmed/26604717
http://dx.doi.org/10.2147/CIA.S90871
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