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Cerebral small vessel disease and Alzheimer’s disease
Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s dise...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629951/ https://www.ncbi.nlm.nih.gov/pubmed/26604717 http://dx.doi.org/10.2147/CIA.S90871 |
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author | Cai, Zhiyou Wang, Chuanling He, Wenbo Tu, Hanjun Tang, Zhengang Xiao, Ming Yan, Liang-Jun |
author_facet | Cai, Zhiyou Wang, Chuanling He, Wenbo Tu, Hanjun Tang, Zhengang Xiao, Ming Yan, Liang-Jun |
author_sort | Cai, Zhiyou |
collection | PubMed |
description | Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer’s disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD. |
format | Online Article Text |
id | pubmed-4629951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46299512015-11-24 Cerebral small vessel disease and Alzheimer’s disease Cai, Zhiyou Wang, Chuanling He, Wenbo Tu, Hanjun Tang, Zhengang Xiao, Ming Yan, Liang-Jun Clin Interv Aging Review Cerebral small vessel disease (CSVD) is a group of pathological processes with multifarious etiology and pathogenesis that are involved into the small arteries, arterioles, venules, and capillaries of the brain. CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger’s disease, and cerebral microbleeds. CSVD is an important cerebral microvascular pathogenesis as it is the cause of 20% of strokes worldwide and the most common cause of cognitive impairment and dementia, including vascular dementia and Alzheimer’s disease (AD). It has been well identified that CSVD contributes to the occurrence of AD. It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD. So far, there is no strong evidence-based medicine to support the idea, although increasing basic studies supported the fact that the treatment and prevention for cerebrovascular diseases will benefit AD. Furthermore, there is still lack of evidence in clinical application involved in specific drugs to benefit both AD and CSVD. Dove Medical Press 2015-10-23 /pmc/articles/PMC4629951/ /pubmed/26604717 http://dx.doi.org/10.2147/CIA.S90871 Text en © 2015 Cai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Cai, Zhiyou Wang, Chuanling He, Wenbo Tu, Hanjun Tang, Zhengang Xiao, Ming Yan, Liang-Jun Cerebral small vessel disease and Alzheimer’s disease |
title | Cerebral small vessel disease and Alzheimer’s disease |
title_full | Cerebral small vessel disease and Alzheimer’s disease |
title_fullStr | Cerebral small vessel disease and Alzheimer’s disease |
title_full_unstemmed | Cerebral small vessel disease and Alzheimer’s disease |
title_short | Cerebral small vessel disease and Alzheimer’s disease |
title_sort | cerebral small vessel disease and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629951/ https://www.ncbi.nlm.nih.gov/pubmed/26604717 http://dx.doi.org/10.2147/CIA.S90871 |
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