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Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease

BACKGROUND: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these...

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Autor principal: Moretti, Davide Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629965/
https://www.ncbi.nlm.nih.gov/pubmed/26604762
http://dx.doi.org/10.2147/NDT.S93253
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author Moretti, Davide Vito
author_facet Moretti, Davide Vito
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description BACKGROUND: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these major landmarks of prodromal AD. METHODS: Clinical and neuropsychological assessment, EEG recording, and high-resolution three-dimensional magnetic resonance imaging were done in 74 grown up subjects with mild cognitive impairment. This information was gathered and has been assessed 3 years postliminary. EEG recording and perfusion single-photon emission computed tomography assessment was done in 27 subjects. Alpha3/alpha2 frequency power ratio, including cortical thickness, was figured for every subject. Contrasts in cortical thickness among the groups were assessed. Pearson’s r relationship coefficient was utilized to evaluate the quality of the relationship between cortical thinning, brain perfusion, and EEG markers. RESULTS: The higher alpha3/alpha2 frequency power ratio group corresponded with more prominent cortical decay and a lower perfusional rate in the temporoparietal cortex. In a subsequent meetup after 3 years, these patients had AD. CONCLUSION: High EEG upper/low alpha power ratio was connected with cortical diminishing and lower perfusion in the temporoparietal brain area. The increase in EEG upper/low alpha frequency power ratio could be helpful in recognizing people in danger of conversion to AD dementia and this may be quality information in connection with clinical assessment.
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spelling pubmed-46299652015-11-24 Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease Moretti, Davide Vito Neuropsychiatr Dis Treat Original Research BACKGROUND: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these major landmarks of prodromal AD. METHODS: Clinical and neuropsychological assessment, EEG recording, and high-resolution three-dimensional magnetic resonance imaging were done in 74 grown up subjects with mild cognitive impairment. This information was gathered and has been assessed 3 years postliminary. EEG recording and perfusion single-photon emission computed tomography assessment was done in 27 subjects. Alpha3/alpha2 frequency power ratio, including cortical thickness, was figured for every subject. Contrasts in cortical thickness among the groups were assessed. Pearson’s r relationship coefficient was utilized to evaluate the quality of the relationship between cortical thinning, brain perfusion, and EEG markers. RESULTS: The higher alpha3/alpha2 frequency power ratio group corresponded with more prominent cortical decay and a lower perfusional rate in the temporoparietal cortex. In a subsequent meetup after 3 years, these patients had AD. CONCLUSION: High EEG upper/low alpha power ratio was connected with cortical diminishing and lower perfusion in the temporoparietal brain area. The increase in EEG upper/low alpha frequency power ratio could be helpful in recognizing people in danger of conversion to AD dementia and this may be quality information in connection with clinical assessment. Dove Medical Press 2015-10-27 /pmc/articles/PMC4629965/ /pubmed/26604762 http://dx.doi.org/10.2147/NDT.S93253 Text en © 2015 Moretti. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Moretti, Davide Vito
Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_full Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_fullStr Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_full_unstemmed Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_short Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_sort association of eeg, mri, and regional blood flow biomarkers is predictive of prodromal alzheimer’s disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629965/
https://www.ncbi.nlm.nih.gov/pubmed/26604762
http://dx.doi.org/10.2147/NDT.S93253
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