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Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma

The aim of this study was to determine the prognostic value of perineural invasion (PNI) in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma (ESCC) who underwent curative resection. A total of 148 patients with (P)T(1–3)N(0)M(0) ESCC, who underwent surgery in Zhejiang Cancer Hospit...

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Autores principales: Sheng, Liming, Ji, Yongling, Du, Xianghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629978/
https://www.ncbi.nlm.nih.gov/pubmed/26604784
http://dx.doi.org/10.2147/OTT.S90909
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author Sheng, Liming
Ji, Yongling
Du, Xianghui
author_facet Sheng, Liming
Ji, Yongling
Du, Xianghui
author_sort Sheng, Liming
collection PubMed
description The aim of this study was to determine the prognostic value of perineural invasion (PNI) in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma (ESCC) who underwent curative resection. A total of 148 patients with (P)T(1–3)N(0)M(0) ESCC, who underwent surgery in Zhejiang Cancer Hospital (Hangzhou, People’s Republic of China), between 2006 and 2009, were evaluated in this retrospective study. The effects of PNI on distant metastasis-free survival (DMFS) and overall survival (OS) were assessed using Kaplan–Meier analysis. Independent prognostic factors were identified by multivariate Cox analysis. Positive PNI was identified in 25.0% of all the cases. The depth of invasion (PT stage) was closely associated with the PNI positivity (P<0.001). The 5-year DMFS rate and OS rate of the PNI-positive patients were significantly worse than those of the PNI-negative patients (DMFS: 37.2% vs 62.3%, P=0.009; OS: 31.3% vs 74.3%, P,0.001). Multivariate analysis indicated that the positivity of PNI was an independent prognostic factor for both DMFS (hazard ratio [HR] =2.35, P=0.039) and OS (HR =3.56, P=0.002). Our results suggest that PNI was a predictor of distant metastasis and independently associated with prognosis of patients with (P)T(1–3)N(0)M(0) ESCC.
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spelling pubmed-46299782015-11-24 Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma Sheng, Liming Ji, Yongling Du, Xianghui Onco Targets Ther Original Research The aim of this study was to determine the prognostic value of perineural invasion (PNI) in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma (ESCC) who underwent curative resection. A total of 148 patients with (P)T(1–3)N(0)M(0) ESCC, who underwent surgery in Zhejiang Cancer Hospital (Hangzhou, People’s Republic of China), between 2006 and 2009, were evaluated in this retrospective study. The effects of PNI on distant metastasis-free survival (DMFS) and overall survival (OS) were assessed using Kaplan–Meier analysis. Independent prognostic factors were identified by multivariate Cox analysis. Positive PNI was identified in 25.0% of all the cases. The depth of invasion (PT stage) was closely associated with the PNI positivity (P<0.001). The 5-year DMFS rate and OS rate of the PNI-positive patients were significantly worse than those of the PNI-negative patients (DMFS: 37.2% vs 62.3%, P=0.009; OS: 31.3% vs 74.3%, P,0.001). Multivariate analysis indicated that the positivity of PNI was an independent prognostic factor for both DMFS (hazard ratio [HR] =2.35, P=0.039) and OS (HR =3.56, P=0.002). Our results suggest that PNI was a predictor of distant metastasis and independently associated with prognosis of patients with (P)T(1–3)N(0)M(0) ESCC. Dove Medical Press 2015-10-27 /pmc/articles/PMC4629978/ /pubmed/26604784 http://dx.doi.org/10.2147/OTT.S90909 Text en © 2015 Sheng et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sheng, Liming
Ji, Yongling
Du, Xianghui
Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title_full Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title_fullStr Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title_full_unstemmed Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title_short Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (P)T(1–3)N(0)M(0) esophageal squamous cell carcinoma
title_sort perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with (p)t(1–3)n(0)m(0) esophageal squamous cell carcinoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629978/
https://www.ncbi.nlm.nih.gov/pubmed/26604784
http://dx.doi.org/10.2147/OTT.S90909
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