Adipokines, diabetes and atherosclerosis: an inflammatory association

Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, includi...

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Autores principales: Freitas Lima, Leandro C., Braga, Valdir de Andrade, do Socorro de França Silva, Maria, Cruz, Josiane de Campos, Sousa Santos, Sérgio H., de Oliveira Monteiro, Matheus M., Balarini, Camille de Moura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630286/
https://www.ncbi.nlm.nih.gov/pubmed/26578976
http://dx.doi.org/10.3389/fphys.2015.00304
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author Freitas Lima, Leandro C.
Braga, Valdir de Andrade
do Socorro de França Silva, Maria
Cruz, Josiane de Campos
Sousa Santos, Sérgio H.
de Oliveira Monteiro, Matheus M.
Balarini, Camille de Moura
author_facet Freitas Lima, Leandro C.
Braga, Valdir de Andrade
do Socorro de França Silva, Maria
Cruz, Josiane de Campos
Sousa Santos, Sérgio H.
de Oliveira Monteiro, Matheus M.
Balarini, Camille de Moura
author_sort Freitas Lima, Leandro C.
collection PubMed
description Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models.
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spelling pubmed-46302862015-11-17 Adipokines, diabetes and atherosclerosis: an inflammatory association Freitas Lima, Leandro C. Braga, Valdir de Andrade do Socorro de França Silva, Maria Cruz, Josiane de Campos Sousa Santos, Sérgio H. de Oliveira Monteiro, Matheus M. Balarini, Camille de Moura Front Physiol Physiology Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models. Frontiers Media S.A. 2015-11-03 /pmc/articles/PMC4630286/ /pubmed/26578976 http://dx.doi.org/10.3389/fphys.2015.00304 Text en Copyright © 2015 Freitas Lima, Braga, do Socorro de França Silva, Cruz, Sousa Santos, de Oliveira Monteiro and Balarini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Freitas Lima, Leandro C.
Braga, Valdir de Andrade
do Socorro de França Silva, Maria
Cruz, Josiane de Campos
Sousa Santos, Sérgio H.
de Oliveira Monteiro, Matheus M.
Balarini, Camille de Moura
Adipokines, diabetes and atherosclerosis: an inflammatory association
title Adipokines, diabetes and atherosclerosis: an inflammatory association
title_full Adipokines, diabetes and atherosclerosis: an inflammatory association
title_fullStr Adipokines, diabetes and atherosclerosis: an inflammatory association
title_full_unstemmed Adipokines, diabetes and atherosclerosis: an inflammatory association
title_short Adipokines, diabetes and atherosclerosis: an inflammatory association
title_sort adipokines, diabetes and atherosclerosis: an inflammatory association
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630286/
https://www.ncbi.nlm.nih.gov/pubmed/26578976
http://dx.doi.org/10.3389/fphys.2015.00304
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