A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results

In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the bioc...

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Detalles Bibliográficos
Autores principales: Ampatzoglou, Pantelis, Dassios, George, Hadjinicolaou, Maria, Kourea, Helen P., Vrahatis, Michael N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630322/
https://www.ncbi.nlm.nih.gov/pubmed/26558163
http://dx.doi.org/10.1186/s40064-015-1417-5
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author Ampatzoglou, Pantelis
Dassios, George
Hadjinicolaou, Maria
Kourea, Helen P.
Vrahatis, Michael N.
author_facet Ampatzoglou, Pantelis
Dassios, George
Hadjinicolaou, Maria
Kourea, Helen P.
Vrahatis, Michael N.
author_sort Ampatzoglou, Pantelis
collection PubMed
description In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the biochemical energy level of the tumor cells and a mechanism that simulates the behavior of cancer stem cells. Numerical simulations of the model are used to investigate the morphology of the tumor at the avascular phase. The obtained results show similar characteristics with those observed in clinical data in the case of the Ductal Carcinoma In Situ (DCIS) of the breast.
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spelling pubmed-46303222015-11-10 A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results Ampatzoglou, Pantelis Dassios, George Hadjinicolaou, Maria Kourea, Helen P. Vrahatis, Michael N. Springerplus Research In the present manuscript we propose a lattice free multiscale model for avascular tumor growth that takes into account the biochemical environment, mitosis, necrosis, cellular signaling and cellular mechanics. This model extends analogous approaches by assuming a function that incorporates the biochemical energy level of the tumor cells and a mechanism that simulates the behavior of cancer stem cells. Numerical simulations of the model are used to investigate the morphology of the tumor at the avascular phase. The obtained results show similar characteristics with those observed in clinical data in the case of the Ductal Carcinoma In Situ (DCIS) of the breast. Springer International Publishing 2015-11-02 /pmc/articles/PMC4630322/ /pubmed/26558163 http://dx.doi.org/10.1186/s40064-015-1417-5 Text en © Ampatzoglou et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Ampatzoglou, Pantelis
Dassios, George
Hadjinicolaou, Maria
Kourea, Helen P.
Vrahatis, Michael N.
A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title_full A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title_fullStr A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title_full_unstemmed A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title_short A chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
title_sort chemical energy approach of avascular tumor growth: multiscale modeling and qualitative results
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630322/
https://www.ncbi.nlm.nih.gov/pubmed/26558163
http://dx.doi.org/10.1186/s40064-015-1417-5
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